![]() ![]() “The CTA will continue to provide information, guidance, and services to passengers and airlines as we make our way through this challenging period.” AccommodationĪs with air travel, hotels’ and other accommodations’ policies on cancellations, rescheduling and refunds vary. “While any specific situation brought before the CTA will be examined on its merits, the CTA believes that, generally speaking, an appropriate approach in the current context could be for airlines to provide affected passengers with vouchers or credits for future travel, as long as these vouchers or credits do not expire in an unreasonably short period of time (24 months would be considered reasonable in most cases). On the other hand, airlines facing huge drops in passenger volumes and revenues should not be expected to take steps that could threaten their economic viability. “On the one hand, passengers who have no prospect of completing their planned itineraries with an airline’s assistance should not simply be out-of-pocket for the cost of cancelled flights. However, the COVID-19 pandemic is happening outside anyone’s control, and while the CTA is still your go-to resource in the case of a dispute with an airline, its website states: Under normal circumstances, the Canadian Transportation Agency’s Air Passenger Protection Regulations require airlines to refund your airfare, plus an inconvenience fee, if your flight is cancelled for a reason that’s within the airline’s control-for example, consolidating two flights into one for the sake of efficiency. Whether you can reasonably expect a refund is a bit, well, up in the air, as the duration of this shutdown, and its economic consequences on both airline customers and the airlines themselves, fall into question. This credit is valid for travel before March 31st, 2021.” You will receive full credit, which you can use towards future travel. “If you made a flight booking before March 31st, 2020, and you want to cancel it, you can do so with no cancellation fee. For example, Air Canada has posted this message on their website: You’re very likely to get some kind of compensation. A good place to start is on their website (especially because there are long wait times to reach representatives via phone). It’s up to you to check with the airline you booked with. Some major airlines, like Delta, will automatically transform your flight into credit that can be used in the future some require you to take a certain action to ensure your travel booking can be transferred to a future date. Will you be able to get a refund on your travel booking? The first step is to check whether the airline you booked with will issue a refund during this global pandemic. Together, let’s look at what can be done to get the refunds you need or at least postpone your trip to when it will be safer to travel again. In the meantime, if you booked a trip that was supposed to happen in April or May-or even beyond-and are afraid of losing everything you paid for, don’t worry: I got you. The Canadian border is now officially closed to all but essential travel, so that trip to Cuba will have to wait. Photo created by yanalya - Whether it’s a trip you booked months ago, or a last-minute deal you snagged when news coverage of the coronavirus was still just a faint rumble, travelling at this time is not an option. ![]()
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Fast Company is the worlds leading progressive business media brand, with a unique editorial focus on innovation in technology, leadership, and design. The Motley Fool Stock Advisor If you’re a long-term investor looking for monthly stock picks, The Motley Fool’s Stock Advisor is the best investment newsletter for you. ![]() If they seem glossed over, they will avoid the online store. Customers today are educated about reviews. For this reason, they are easy to recognize as fake. Purchased reviews are usually vague and sound formulaic. Apart from the fact that it is hardly morally justifiable, you will only receive some generic texts from random people. has reviewed and ranked the best investment newsletters available today.I do not recommend that online store owners resort to purchased reviews. Also, be aware of any refund policies in place, in case you choose to subscribe and later decide it's not offering the investment advice Be sure to look for a free issue or risk-free trial period. Most services providing investment newsletters want you to know what you're getting ahead of time they're not in the business of tricking you out of your hard-earned money. Check out the track record of success for any newsletter you're considering - it's worth it to spend more for the advice if it means you'll get gains of a degree of magnitude larger than a less-expensive With numerous 5-star reviews from loyal year-after-year subscribers, a 30-day money-back guarantee on paid memberships and unlimited free access to basic features, this service has something for almost every long-term investor - from private investors to professional money managers. Notice we didn't say "cost" or "price" - because some of the more expensive investment newsletters also have the potential to help you reap the greatest rewards. ![]() Are you the kind of investor that wants an update on a daily basis, so that you can capitalize on emerging opportunities? Or would that overwhelm you? Some newsletters are strictly monthly, while others may include daily, weekly, or as-needed updates through an online portal and/or email alerts. You'll need to have a general idea of what kind of advice you want before you can choose the best investment newsletter for your situation. Others are hyper-focused on one specific sector, type of stock, or fund family. Some investment newsletters are broad, aimed at the everyday investor who just wants to know which stocks are likely to provide safe and reliable growth over time. Start and end your work day with the stories that matter from Mike Allen. 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Investment newsletters can help you focus your investments on a wide range of stocks, bonds and mutual funds - or give you a laser-like focus on one particular sector or strategy. I am the editor of three Forbes investment newsletters: Forbes Dividend Investor, Forbes Billionaire Investor and covered call writing advisory service. ![]() ![]() In particular, the Company’s statements regarding trends and potential future results are examples of such forward-looking statements. We may, in some cases, use terms such as “predicts,” “believes,” “potential,” “continue,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. The Company may occasionally disseminate material, nonpublic information on the company website.Ĭertain matters discussed in this press release are “forward-looking statements”. For more information, please visit the Company’s website at. At Axsome, we are intensely committed to developing products that meaningfully improve the lives of patients and provide additional therapeutic options for physicians. Through development of therapeutic options with novel mechanisms of action, we are transforming the approach to treating CNS conditions. is a biopharmaceutical company developing novel therapies for central nervous system (CNS) conditions that have limited treatment options. ![]() ![]() AXS-12 is an investigational drug product not approved by the FDA.Īxsome Therapeutics, Inc. Food and Drug Administration (FDA) Orphan Drug Designation for the treatment of narcolepsy. AXS-12 modulates noradrenergic activity to promote wakefulness, maintain muscle tone and enhance cognition. Narcolepsy interferes with cognitive, psychological, and social functioning, increases the risk of work- and driving-related accidents, and is associated with a 1.5-fold higher mortality rate.ĪXS-12 (reboxetine) is a highly selective and potent norepinephrine reuptake inhibitor under development for the treatment of narcolepsy. Cataplexy is seen in an estimated 70% of narcolepsy patients and is a sudden reduction or loss of muscle tone while a patient is awake, typically triggered by strong emotions such as laughter, fear, anger, stress, or excitement. Narcolepsy afflicts an estimated 185,000 individuals in the U.S. Narcolepsy is a serious and debilitating neurological condition that causes dysregulation of the sleep-wake cycle and is characterized clinically by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, sleep paralysis, and disrupted nocturnal sleep. Other symptoms of narcolepsy as well as safety will be assessed throughout the study. The primary endpoint will be the frequency of cataplexy attacks. Approximately 90 patients will be randomized in a 1:1 ratio to treatment with AXS-12 or placebo for 5 weeks. ![]() SYMPHONY (Study Evaluating a Mechanistic Approach to Treating Narcolepsy) is a Phase 3, randomized, double-blind, multicenter, placebo-controlled trial to assess the efficacy and safety of AXS-12 in patients with narcolepsy. Food and Drug Administration for the treatment of narcolepsy. If successfully developed, AXS-12 may address multiple symptoms of this debilitating condition.”ĪXS-12 has been granted Orphan Drug Designation by the U.S. “Narcolepsy impairs almost every aspect of a patient’s life including cognitive, psychological, social, and emotional functioning. “The advancement of AXS-12 into Phase 3 testing for narcolepsy demonstrates Axsome’s commitment to developing important new medicines for patients living with serious CNS conditions,” said Herriot Tabuteau, MD, Chief Executive Officer of Axsome. Topline results from the SYMPHONY trial are anticipated in the first half of 2023. ![]() AXS-12 is a novel, oral, potent, and highly selective norepinephrine reuptake inhibitor. (NASDAQ: AXSM), a biopharmaceutical company developing novel therapies for the management of central nervous system (CNS) disorders, enrolled the first patient in SYMPHONY (Study Evaluating a Mechanistic Approach to Treating Narcolepsy), a Phase 3, randomized, double-blind, placebo-controlled trial of AXS-12 in patients with narcolepsy. 16, 2021 (GLOBE NEWSWIRE) - Axsome Therapeutics, Inc. ![]() ![]() ![]() ![]() The laser and optical alignments are set and locked down during the manufacturing of the instrument. The Accuri is equipped with two 20mW lasers (488nm and 552nm) and 6 parameters for detection, which include 2 light scatter parameters (forward scatter and side scatter) and 4 parameters for acquiring fluorescence. To schedule Assisted Use or Training please contact Richard Salinas.įees: Trained user: $38/hour. Assisted use: $98/hour BD Accuri SORP Flow Cytometer Instrument Access: Assisted use and training is available. Instrument Configuration: Fortessa Config Fluorescence Spectrum Analyzer (BD Biosciences) The Fortessa only accepts 5mL polystyrene tubes, or 96- and 384-multi-well plates if using the HTS unit. Sample analysis can also be done using Flowjo or FCS Express (both available to use in NMS2.114). Sample acquisition and analysis is done using FACSDiva v6.1.3. In addition, this system is also equipped with the FACSFlow Supply System to allow larger volume tanks for sheath and waste, as well as improved fluidic stability. This instrument can be connected to the optional High Throughput Sampler (HTS) unit to accommodate automated specimen handling for 96- and 384-well plates. Swim Team in Tokyo.The Fortessa is equipped with four lasers (405nm, 488nm, 561nm and 635nm) and 15 parameters for detection, which includes 2 light scatter parameters (forward and side scatter) and 13 fluorescence parameters. team, Speedo also created the official swimsuits for Canada, Australia and several other countries. The athletes will be utilizing the Fastskin LZR Pure Intent suit, which features three new fabrics designed to help improve flexibility, compression and drag reduction and the Fastskin LZR Pure Valor, which has moderate compression and bonded seams to maximize comfort and speed. Federation swimsuits, which will be worn by superstars like Caeleb Dressel, Ryan Murphy, Abbey Weitzeil and Hali Flickinger. This year for the Tokyo Games, Speedo once again built the U.S. Sport Climbing athletes in the Summer Olympics. The North Face created performance uniforms for the U.S. The sleek pieces, featured in a deep navy and crisp white, for both men and women, offer a sophisticated and exceedingly tailored aesthetic that brings a freshness to the sport, all under the ethos “built by climbers, for climbers.” The longstanding outdoor brand has also created the team uniforms for Japan, South Korea and Austria. Courtesy of Skims The North FaceĪs sport climbing makes its Olympic debut in Tokyo, The North Face has taken on the creation of the competition uniforms for the U.S. As I would watch the athletes compete, I would grow to understand the dedication and honor being a part of the Olympics embodied.” Dalilah Muhammad in Team USA Skims collection. As the step-daughter of former Olympian Caitlyn Jenner, Kardashian wrote on Twitter, “Ever since I was 10 years old, I’ve heard every single detail about the Olympics from my stepdad. With this collaboration, all 626 female athletes participating in the games in Tokyo will receive the full line that has been developed in breathable, premium fabrics for cooling down, recovering and sleeping. Kim Kardashian’s brand Skims entered a licensing deal with Team USA, which includes a limited-edition collection of undergarments, sleepwear and loungewear designed for U.S. ![]() ![]() ![]() This game, in particular, appeared for the first time on Dreamcast, and later on PC, Game Boy Advance, and Nokia N-Gage. ![]() Within this collection, we can find titles of the likes of Altered Beast, Sonic or Comix Zone, classic titles that are part of the history of video gaming both on arcade machines and 8 and 16-bit video consoles and computers. The game has been re-edited within the SEGA Forever collection, adapting to APK format for Android and iPhone, some of the most legendary games of the Japanese developer. 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Hello Neighbor is getting a sequel for Xbox Series X, Xbox One, and PC. The post Hello Neighbor Alpha 4 appeared first on Surf 365. Until the sequel drops, you have come to our website to play Hello Neighbor Games online from your browsers or mobile devices, something we definitely appreciate, because you knew that here you would find the best original and fan-made games based around this franchise, whether you test your knowledge of the series, try the alpha version, solve. Published Hello Neighbor 2 is coming soon to Xbox platforms and PC, and will directly follow the events of the original. This supermarket also exists in Alpha 4 and all subsequent versions. It has no collision data in this version. ![]() the player can find a supermarket known as 'The Golden Apple'. Download for Free, Multiplayer supported. This page lists secrets and easter eggs from the full game of Hello Neighbor, and secrets and easter eggs from the Alpha and Beta versions before the release of the. Play against an advanced, self-learning AI that tracks and adapts to your every move. Play with good stereo.įull Game, Latest version. Hello Neighbor 2 Alpha 1.5 is OUT NOW This newest Halloween update improves virtually every gameplay aspect Hello Neighbor 2 - the sequel to the genre-defining stealth horror game. Graphics:Dedicated video card is required Release Date: 19 Oct, 2019 System Requirements ![]() Sandbox-style gameplay with plenty of environmental interaction and physics.Constantly evolving experience where the Neighbor’s AI counters your moves, and learns from what you do.Although this game is playable on PS5, some features available on PS4 may be absent. Suspenseful horror gameplay that focuses on sneaking around your neighbor’s house Release: Publisher: tinyBuild GAMES Genre: Action, Adventure, Horror To play this game on PS5, your system may need to be updated to the latest system software.Trying to escape? The Neighbor will find a shortcut and catch you. Sneaking through the front door? There’ll be cameras there soon. Really enjoying climbing through that backyard window? Expect a bear trap there. You play against an advanced AI that learns from your every move. Welcome back to Hello Neighbor In this Hello Neighbor video, we take a look at the secrets and teasers that the developers have shown for the secret Hello N. Hello Neighbor is a stealth horror game about sneaking into your neighbor’s house to figure out what horrible secrets he’s hiding in the basement. Search and find items, hide in new containers, make your foe even more furious.Hello Neighbor Alpha 4 Free Download About This Game Hello Neighbor Alpha 4 is unique in its kind, here you need to make every attempt to get the annoying man, download via torrent and come up with your own ways. He will begin to plunge into memories and thoughts, and at this moment you will prepare a new trick for him. Throw the largest number of toys found for your uncle. 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The series director, known as “ToT,” revealed on Twitter that the production for Season 4 is expected to wrap up in November 2023. However, there is some disappointing news as well-no official release date has been confirmed as of yet. A successful Kickstarter campaign was launched on June 8, 2020, to fund the production of the new season, putting any worries to rest. Ankama Animations recently announced on May 7, 2020, that Season 4 is currently in the works. The exciting news is on the horizon for fans of Wakfu: Season 4. ![]() Is there any Wakfu Season 4 Trailer Released Yet?. ![]() ![]() ![]() To access them, you’ll need a Microsoft account-which is easy to register to since it’s free. Unlike other office suites like LibreOffice, Microsoft Office 2021 doesn’t offer any free versions aside from its free 1-month trial and its online web app. How can I install Microsoft Office for free? 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